Why I stopped retatrutide after two weeks.

J'ai perdu 4,2 kg en deux semaines sous rétatrutide.

Then I stopped.

Not because of the cost. Not because I could not stick with it. Because my data was heading the wrong way.

When retatrutide works, you feel it fast

• moins de food noise
• very fast weight loss

And for me, more focus.

Probably because I had fewer blood-sugar crashes.

In training, I had energy.

I ate less, but I ate.

The disaster story you read everywhere, I did not live it.

On reta, resting heart rate can climb

It is in the phase 2 trial, in the New England Journal of Medicine.

The rise is dose-dependent. At 8 and 12 mg weekly: 5 to 7 beats per minute.

Two honest caveats.

It peaks at week 24, then it declines.

And in that trial it was not associated with any cardiovascular event.

For scale: tirzepatide rises 1 to 3 bpm. Semaglutide, 1 to 4.

Retatrutide does more. That is the price of a triple agonist.

Bryan Johnson stopped his microdosing for the same reason.

Three weeks. Resting heart rate +3 bpm, variability −7, sleep −10%.

The most obsessive man in longevity stops on numbers, not on a feeling.

The 2nd side effect: losing muscle

Part of the weight lost is not fat. It is lean mass.

So muscle.

Estimates vary, but the range is wide: between a quarter and 40% of the weight lost.

STEP 1 and SUSTAIN 8 reach 39-40%. Other meta-analyses land around 25%.

A word on what you cannot measure yourself.

Smart scales infer body composition. They do not measure it.

Reliable on weight. Not reliable enough on composition.

So nobody, me included, can claim a muscle-loss figure from a scale.

4 priorities if you use reta

• a genuinely data-driven approach: a watch or a band, to track how your numbers move
• at least 1.2 g of protein per kilo per day
• 2 to 4 strength sessions a week
• real sleep: regular, calm, no coffee late

I stopped after two weeks because my numbers were getting worse.

Not the cost. Not willpower. Data.

Until the next edition, take care.